increase spinal fluid in brain ventricles quizlet

Within this model, CSF is secreted actively by the choroid plexuses (CPs) and secretory epithelia in the lateral, third and fourth cerebral ventricles. Throughout the course of the 20 th Century, painstaking surgical, physiological and biophysical experiments led to the development of a classical description of CSF secretion, circulation and reabsorption that remains the principal model to this day. Contributions to CNS development and repair mechanisms have also been noted. CSF also serves regulatory functions, including distribution of neurotrophic factors and stabilization of brain pH and chemical gradients, in addition to supplying an excretory pathway out of CNS for solutes that cannot readily cross the blood brain barrier (BBB). CSF provides buoyancy to support the weight of the brain and acts as a protective layer to cushion it from injury. Ongoing research within this field may provide a powerful new framework for understanding the common links between neurodegenerative, neurovascular and neuroinflammatory disease, in addition to providing potentially novel therapeutic targets for these conditions.Ĭerebrospinal fluid (CSF), a clear, secreted fluid filling the cerebral ventricles and surrounding the brain and spinal cord within the subarachnoid space (SAS), serves several functions in the central nervous system (CNS).

Dysfunction within this glial vascular network, which is a feature of the aging and injured brain, is a potentially critical link between brain injury, neuroinflammation and the development of chronic neurodegeneration. Recent insights into CSF biology suggesting that CSF and interstitial fluid exchange along a brain-wide network of perivascular spaces termed the ‘glymphatic’ system suggest that CSF circulation may interact intimately with glial and vascular function to regulate basic aspects of brain function. Disruption of normal CSF circulation and turnover is believed to contribute to the development of many diseases, including neurodegenerative conditions such as Alzheimer’s disease, ischemic and traumatic brain injury, and neuroinflammatory conditions such as multiple sclerosis. Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of solutes from the brain interstitium, serving an important homeostatic role for the function of the central nervous system.

Increase spinal fluid in brain ventricles quizlet